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True toxic effects of various alkyl nitrites

Posted on Poppers Guide's Forum

Topic created by The Professor
on Wed, 15 Sep 2021 at 23:24

The Professor said on Wed, 15 Sep 2021 at 23:24...

this is a data dump from a conversation on reddit between ken jones ( as poppermaker), and popchef2 regarding toxicity of alkyl nitrites

I've delimited the data to only ONE type of test subject (rats) and only ONE exposure type (inhalation for 4 hours)

Klonne et al. 1987
(4-hour exposures)
Alkyl nitrite lethal concentration median inhalation LC50

Ethyl Nitrite 160 ppm
Methyl 176 ppm
n-Propyl 300 ppm

Isopentyl 716 ppm
Isobutyl 777 ppm
n-Butyl 4210 ppm

data for n-amyl nitrite for rats at 4 hour inhalation exposure is unavailable, but comparison can be taken from intraperitoneal LD50s of mice

Mcfadden and Maickel 1979
peritoneal injection (30-minute LD50)

n-Amyl nitrite 30 mg/kg
n-Butyl nitrite 158 mg/kg
isobutyl nitrite 169 mg/kg
sec-Butyl nitrite 592 mg/kg
tert-Butyl nitrite 625 mg/kg

This is NOT my data, it's NOT BS or confusing or any of the other slight of hand attributes that ken Jones tries to stick to me. The data has no agenda, the data is not trying to hide anything from you; the data does not lie

You can observe that, in fact, isoAmyl nitrite is more lethal than ANY butyl based nitrite, and the butyl toxicities drop with isomer variants.

the researches didn't try to kill rats for 4 hours, but there is a way to compare relative toxicities by looking at the intraperitoneaL injection death rates, in which normal Amyl is more lethal than normal butyl

Expect the typical hemming and hawing from mortimer.......

Nitritespecialist said on Thu, 16 Sep 2021 at 14:40...

There have been few studies comparing the relative toxicities of alkyl nitrites on human recreational users. Lethal doses on lab rats/mice is not going to give sufficient information that can be applied directly to human recreational users, who are inhaling a wide range of impure poppers.

I don't need a study to tell me which nitrites give me the most side effects. I know it from lots of practical experience whiffing. The Professor, as usual, is trying to discount my lived experience by blaming ME. It's just like the victims of sexual abuse(gymnasts) who were being blamed by the FBI agents for their abuse. This is what unethical and uncaring people do.

The Professor said on Thu, 16 Sep 2021 at 17:34...

Can't you wait with trying to play the victim? It didn't work for you on poppers place or Reddit. Those forums saw through your lies.

So you really want to go through that time loop again? With the same lie?

Isn't doing the same thing, but expecting different results, insanity?

Again and again and Saladin you miss the point.... You DO need a reference, because of you are going to advise OTHER people (as in your opinion that anything above N-Amyl will kill you), then others should know that YOUR experiences with self made nitRATes has nothing to do with an unbiased comparison of nitRITes.

That chicken you keep banging is almost underground Ken; too late to quit while you're ahead

The Professor said on Thu, 16 Sep 2021 at 18:04...


R. Don said on Thu, 16 Sep 2021 at 19:05...

When it comes to popper toxicity nothing, and I mean nothing is more toxic than iso propyl nitrite. It causes breathing problems, eye damage and plummeting oxygen levels. I feel sorry for the rats

The Professor said on Thu, 16 Sep 2021 at 19:10...


Yep, imagine what they must go through; poor things

The Professor said on Thu, 16 Sep 2021 at 21:20...

more real data:

Orally, nitrates are rapidly absorbed from the small intestine. Regardless of exposure route, nitrates are delivered to the intestine via blood circulation and converted, primarily by bacterial oxidation, to the more
reactive nitrites; therefore, nitrites are expected to have lower LD50 and LC50 values than nitrates (Bruning-Fann and Kaneene 1993). For example, the LC50 value for methyl nitrate in rats is 1275 ppm/4 hr; the LC50 for the corresponding nitrite is seven times lower (176 ppm/4 hr).(a)

The Professor said on Thu, 16 Sep 2021 at 22:24...

Comparison of detrimental effects of NTRATES vs NITRITES

The existing data on health effects of inhalation, oral, and dermal exposure of humans and animals to
nitrate and nitrite are summarized in Figures 3-5 and 3-6. The purpose of this figure is to illustrate the
existing information concerning the health effects of nitrate and nitrite. Each dot in the figure indicates
that one or more studies provide information associated with that particular effect.

for nitrates: https://imgur.com/gallery/uAkK0G0

for nitrites: https://imgur.com/gallery/gEaGBrm

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